Download Annual Reports in Medicinal Chemistry, 3 by C K Cain PDF

By C K Cain

ANNUAL stories IN MED CHEMISTRY V3 PPR.

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The opportunity to develop novel psychoactive steroids remains a challenge to medicinal chemists. Pr OiY lNb Y4 O i r 18 (A-10749) - 19 iprindole m i n d o l eR 20 protript line yivacti1'- 11. CENTRAL STIMULANTS Chemistry In contrast to the efforts in the field of antidepressants, relatively little work on central stimulants was reported. The structureactivity relationship of amphetamine derivatives was studied by a molecular orbital method 74. The greatest central stimulant effect was associated with those compounds having the lmest negative charge on the ring carbon atom ortho to the side-chain and with the lowest dipole moment arising from Chap.

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H. Vogel, C. D. Ahlberg, V. D. Carlo and M. K. Horwitt, Nature, 216, 1038 (1967). 133. A. A. BOUltOn, R. J. Pollett and J. R. Majer, Nature, 215, 132 (1967). 134. C. H. Williams, Proc. R. SOC. Med. 60, 5 5 8 (1967). 135. T. L. Perry, S. Hansen and L. MacDougall, Nature, 214, 484 (1967). 136. K. Closs and N. Wad, Nature, 214, 483 (1967). 137. A. Faurbye and K . Pind, Nature, 215, 1387 (1967). 138. Y. Kakimoto, I. Sano, A. Kanazawa, T. Tsujio and 2. Kaneko, Nature, 216, 1110 (1967). 139. A. Hoffer, H.

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