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The opportunity to develop novel psychoactive steroids remains a challenge to medicinal chemists. Pr OiY lNb Y4 O i r 18 (A-10749) - 19 iprindole m i n d o l eR 20 protript line yivacti1'- 11. CENTRAL STIMULANTS Chemistry In contrast to the efforts in the field of antidepressants, relatively little work on central stimulants was reported. The structureactivity relationship of amphetamine derivatives was studied by a molecular orbital method 74. The greatest central stimulant effect was associated with those compounds having the lmest negative charge on the ring carbon atom ortho to the side-chain and with the lowest dipole moment arising from Chap.

Gen. , 16, 162 (1967). 120. R. W. Colburn, F. K. Goodwin, W. E. Bunney and J. M. Davis, Nature, 215, 1395 (1967). 121. J. Clausen and B. Formby, Nature, 213, 389 (1967). Chap. 1 Antipsychotics, Anti-Anxiety A g e n t s P a c h t e r , Rubin 13 - 122. J. J. Schildkraut, S. M. Schanberg, G. R. Breese and I. J. Kopin, Am. J. , 124, 6 0 0 (1967). 123. H. Corrodi, K. Fuxe, T. Hokfelt and M. Schou, Psychopharmacologia, 345 (1967). 124. H. Weil-Malherbe in "Advances in Enzymology", F. F. , Interscience, New York, 1967, pp.

H. Vogel, C. D. Ahlberg, V. D. Carlo and M. K. Horwitt, Nature, 216, 1038 (1967). 133. A. A. BOUltOn, R. J. Pollett and J. R. Majer, Nature, 215, 132 (1967). 134. C. H. Williams, Proc. R. SOC. Med. 60, 5 5 8 (1967). 135. T. L. Perry, S. Hansen and L. MacDougall, Nature, 214, 484 (1967). 136. K. Closs and N. Wad, Nature, 214, 483 (1967). 137. A. Faurbye and K . Pind, Nature, 215, 1387 (1967). 138. Y. Kakimoto, I. Sano, A. Kanazawa, T. Tsujio and 2. Kaneko, Nature, 216, 1110 (1967). 139. A. Hoffer, H.

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